Research Article

Minimizing Off-Target Effects of CRISPR-Cas9 With Optimized sgRNA: Evaluation of Efficiency and Specificity in the Tumor Protein 53 (TP53) Region
CRISPR-Cas9 is a widely used genetic tool with therapeutic potential in molecular biology. CRISPR-Cas9 enables precise genome editing …
Ali Mertcan Köse, Monia Ranalli, Drenka Trivanovic, Irina Maslovaric
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Minimizing Off-Target Effects of CRISPR-Cas9 With Optimized sgRNA: Evaluation of Efficiency and Specificity in the Tumor Protein 53 (TP53) Region
Evaluating Individual, Professional, and Work Environment Characteristics That Impact Intensive Care Nurses' Attitudes Toward Wasteful Behaviors
This study aims to examine the relationships between intensive care nurses’ individual, professional, and work environment …
Cennet Çi̇ri̇ş Yildiz, Seda Değirmenci Öz, Ece Uysal Kasap, İrem Korkmaz, Ali Mertcan Köse
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Psychometric evaluation of the monkey pox fear scale in theTurkish general population
We assessed the psychometric properties of the monkeypox fear scale (MFS) and examined the psychological impact of MPOX on the Turkish …
Merve İnan-Budak, Ali Mertcan Köse
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Radiation protection knowledge and training needs among dental healthcare workers in Turkey
ObjectivesThis study evaluated radiation protection knowledge among oral and dental healthcare professionals in Turkey, focusing on …
Emine Nur Kahraman, Burak Bayrı, Özge Ulu, Ali Mertcan Köse, Idil Görkem Gün, Emre Azar
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Workplace Violence Against Nurses and Its Effects on Some Organisational Outcomes: A Cross-Sectional Survey
Aim: The study focuses on the effects of workplace violence on certain organisational outcomes, such as job performance, burnout, …
Cennet Çiriş Yıldız, Seda Değirmenci Öz, Hülya Ulaşli Kaban, Ali Mertcan Köse
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Prevalence Estimation Using a Depression Screening Tool in the National Health and Nutrition Examination Survey: Comparison of Different Cutoffs
Objectives: The National Health and Nutrition Examination Survey (NHANES) in the US relies on the depression screening tool PHQ-9 to …
Ali Mertcan Köse, Paul Petzold, Dario Zocholl, Polychronis Kostoulas, Matthias Rose, Felix Fischer
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Inspecting smoking addiction in youth in Türkiye: A latent class analysis using the Turkish version of the cigarette dependence scale
Recent significant studies have focused on whether smoking behavior is a voluntary choice or an addiction. Inspired by these studies, …
Elif Ünal Çoker, Ali Mertcan Köse
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Unveiling off-target mutations in CRISPR guideRNAs:Implications for gene region specificity
The revolutionary CRISPR-Cas9 technology has revolutionized genetic engineering, and it holds immense potential for therapeutic …
Ali Mertcan Köse, Ozan Kocadağlı, Cihan Taştan, Çağdaş Aktan, Onu Mert Ünaldı, Elanur Güzenge, Hamza Emir Erdil
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Psychometric evaluation of the Social Support Questionnaire for Transactions in Turkish gender-based violence sample
Aim: This study aims to investigate the reliability and predictive validity of the Social Support Questionnaire for Transactions (SSQT) …
Merve İnan-Budak, Zeynep Zonp, Ali Mertcan Köse, Denise M. Saint-Arnault
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Evaluation of Treatment Responses among Subgroups of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
Background: Breast MRIs are helpful for determining treatment plans, responses, and prospective survival analyses. In this …
Sevinç Dağostanlı, Süleyman Sönmez, Nilüfer Bulut, Ali Mertcan Köse
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